Functional imaging of hepatocellular carcinoma

Hepatocellular Carcinoma in Sheep

Functional genomics of hepatocellular carcinoma.

The majority of DNA-microarray based gene expression profiling studies on human hepatocellular carcinoma (HCC) has focused on identifying genes associated with clinicopathological features of HCC patients. Although notable success has been achieved, this approach still faces significant challenges due to the heterogeneous nature of HCC (and other cancers) as well as the many confounding factors...

Breakthrough Imaging in Hepatocellular Carcinoma

The ultrasound (US) contrast agent, SonoVue®, has been approved for use worldwide. Conversely, Sonazoid®, which was approved in Japan ahead of other countries in January 2007, is also currently used in Korea, China, and Norway, although its use is gradually spreading to other countries. Sonazoid®-enhanced US is considered a breakthrough imaging technology because it has drastically changed clin...

Hepatocellular carcinoma—issues in imaging

The imaging diagnosis of hepatocellular carcinoma is challenging as benign hypervascular lesions and arterioportal shunts (pseudolesions) often mimic it. There is also overlap in the imaging appearance from dysplastic and regenerating nodules. This article addresses the above imaging problems, examines proposed non-invasive imaging criteria for the diagnosis of hepatoma and discusses the optima...

Hepatocellular carcinoma in a sheep

At necropsy of a five-year-old sheep, a pear shaped, lobular yellow-brownish mass measuring about 12 ×15 × 20 cm was found to involve the right hepatic lobe. Microscopic examination revealed two trabecularand solid patterns of neoplastic hepatocytes. In solid pattern, there were numerous tumoral giant cells thatcontain one or more large hyperchromatic bizarre-shaped nuclei scattered among clust...